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Study Examines Magnesium Citrate in the Treatment of Chronic Persistent Leg Cramps
SOURCE: Blaine Pharmaceuticals
9:48AM, September 16, 2005
Persistent leg cramps are a common problem that affects 30% of people over the age of 60 and increases to 50% of people over the age of 80. Cramps may be caused by changes in electrolyte homeostasis, or by medications. The only proven treatment is quinine sulfate, which can cause significant side effects. As magnesium salts have demonstrated effectiveness in the treatment of pregnancy-associated leg cramps, a study in the May 2002 Medical Science Monitor (2002 May;8(5):CR326-30), examined the effectiveness of magnesium citrate in the treatment of chronic leg cramps in non-pregnant subjects.
Forty-six participants with stable patterns of two or more cramps per week for three months were randomized into this cross-over, placebo controlled trial utilizing magnesium citrate equivalent to 300 mg. magnesium daily vs. matching placebo for six weeks. Overall, there were fewer cramps during the magnesium phases than during placebo, but the difference was not significant. The authors note that a higher dose of magnesium may have proved more effective, as the lower end of the dosage range was chosen. There was a strong period effect (p = 0.008), with more cramps in the first phase than the second.
This study did not use Mag-Ox 400®. However, Mag-Ox 400 is the #1 doctor recommended magnesium supplement – it has four times the magnesium per tablet than other leading brands with a 35% smaller tablet. This Pharmaceutical Grade product offers a 99% dissolution level compared to 38-48% dissolution levels found in leading generics. The dosing for Mag-Ox 400 is two tablets daily.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
For additional information visit
www.magox.com
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